• AI Risk Score on Screening Mammograms Preceding Breast Cancer Diagnosis 

      Larsen, Marthe; Olstad, Camilla Flåt; Koch, Henrik Wethe; Martiniussen, Marit Almenning; Hoff, Solveig Kristin Roth; Lund-Hanssen, Håkon; Solli, Helene; Mikalsen, Karl Øyvind; Auensen, Steinar; Nygård, Jan Franz; Lång, Kristina; Chen, Yan; Hofvind, Solveig Sand-Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-17)
      More than 38% of both screen-detected and interval cancers were assigned the highest artificial intelligence risk score on screening mammograms that preceded breast cancer diagnosis.<p> <p>Background - Few studies have evaluated the role of artificial intelligence (AI) in prior screening mammography.<p> <p>Purpose - To examine AI risk scores assigned to screening mammography in women who were ...
    • Artificial Intelligence Evaluation of 122969 Mammography Examinations from a Population-based Screening Program 

      Larsen, Marthe; Aglen, Camilla Flåt; Lee, Christoph I.; Hoff, Solveig Roth; Lund-Hanssen, Håkon; Lång, Kristina; Nygård, Jan Franz; Ursin, Giske; Hofvind, Solveig Sand-Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-29)
      Background - Artificial intelligence (AI) has shown promising results for cancer detection with mammographic screening. However, evidence related to the use of AI in real screening settings remain sparse.<p> <p>Purpose - To compare the performance of a commercially available AI system with routine, independent double reading with consensus as performed in a population-based screening program. ...
    • Artificial intelligence in BreastScreen Norway: a retrospective analysis of a cancer-enriched sample including 1254 breast cancer cases 

      Koch, Henrik Wethe; Larsen, Marthe; Bartsch, Hauke; Kurz, Kathinka Dæhli; Hofvind, Solveig Sand-Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-14)
      Objectives To compare results of selected performance measures in mammographic screening for an artifcial intelligence (AI) system versus independent double reading by radiologists.<p> <p>Methods In this retrospective study, we analyzed data from 949 screen-detected breast cancers, 305 interval cancers, and 13,646 negative examinations performed in BreastScreen Norway during the period from 2010 ...
    • Artificial intelligence-supported screen reading versus standard double reading in the Mammography Screening with Artificial Intelligence trial (MASAI): a clinical safety analysis of a randomised, controlled, non-inferiority, single-blinded, screening accuracy study 

      Lång, Kristina; Josefsson, Viktoria; Larsson, Anna-Maria; Larsson, Stefan; Högberg, Charlotte; Sartor, Hanna; Hofvind, Solveig Sand-Hanssen; Andersson, Ingvar; Rosso, Aldana (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-01)
      Background - Retrospective studies have shown promising results using artificial intelligence (AI) to improve mammography screening accuracy and reduce screen-reading workload; however, to our knowledge, a randomised trial has not yet been conducted. We aimed to assess the clinical safety of an AI-supported screen-reading protocol compared with standard screen reading by radiologists following ...
    • Breast cancer missed at screening; hindsight or mistakes? 

      Hovda, Tone; Larsen, Marthe; Romundstad, Linda; Sahlberg, Guro Kristine Kleivi; Hofvind, Solveig Sand-Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-03)
      Purpose - To investigate radiologists’ interpretation scores of screening mammograms prior to diagnosis of screen-detected and interval breast cancers retrospectively classified as missed or true negative.<p> <p>Methods - We included data on radiologists’ interpretation scores at screening prior to diagnosis for 1223 screen-detected and 1007 interval cancer cases classified as missed or true ...
    • Costs and Effects of Implementing Digital Tomosynthesis in a Population-Based Breast Cancer Screening Program: Predictions Using Results from the To-Be Trial in Norway 

      Moger, Tron Anders; Holen, åsne Sørlien; Hanestad, Berit; Hofvind, Solveig Sand-Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-07)
      Background Although several studies from Europe and the US have shown promising screening results favoring digital breast tomosynthesis compared with standard digital mammography (DM), both costs and efects of implementing tomosynthesis in routine screening programs remain uncertain. The cost efectiveness of using tomosynthesis in routine screening is debated in the literature, and model inputs ...
    • Differences in mammography screening attendance among non-Western immigrants in Denmark, Finland, Iceland and Norway 

      Njor, Sisse Helle; Heinävaara, Sirpa; Stefansdóttir, Hrefna; Nygård, Mari; Guðmundsdóttir, Eva María; Bhargava, Sameer; Leivonen, Aku; Campbell, Suzanne; Søborg, Bo; Hofvind, Solveig Sand-Hanssen; Sarkeala, Tytti; Vejborg, Ilse; Lamminmäki, Maarit (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-22)
      Several studies have shown that attendance rates are lower among non-Western immigrants than among natives. As the Nordic countries have quite similar health systems and populations but also differences in the organisation of their organised mammography screening programmes, differences in attendance rates could highlight organisational factors that might increase the attendance rates. Mammography ...
    • The dose-response relationship of pre-menopausal alcohol consumption with age at menopause: a population study of 280 497 women in Norway 

      Langås, Julie Røgler; Eskild, Anne; Hofvind, Solveig Sand-Hanssen; Bjelland, Elisabeth Krefting (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-03)
      Background: Previous research suggests that alcohol consumption is associated with high age at menopause. Yet, knowledge about the dose– response relationship is inconsistent. Thus, we studied the pattern of the association of pre-menopausal alcohol consumption with age at natural menopause.<p> <p>Methods: We performed a retrospective population-based study using self-reported data from 280 497 ...
    • Early performance measures following regular versus irregular screening attendance in the population-based screening program for breast cancer in Norway 

      Thy, Jonas Evensen; Larsen, Marthe; Vigeland, Einar; Koch, Henrik Wethe; Hovda, Tone; Hofvind, Solveig Sand-Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-11)
      Irregular attendance in breast cancer screening has been associated with higher breast cancer mortality compared to regular attendance. Early performance measures of a screening program following regular versus irregular screening attendance have been less studied. We aimed to investigate early performance measures following regular versus irregular screening attendance. Methods We used information ...
    • Early screening outcomes among non-immigrants and immigrants targeted by BreastScreen Norway, 2010–2019 

      Thy, Jonas Evensen; Bhargava, Sameer; Larsen, Marthe; Akslen, Lars Andreas; Hofvind, Solveig Sand-Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-31)
      Aims: This study aimed to analyse results on early screening outcomes, including recall and cancer rates, and histopathological tumour characteristics among non-immigrants and immigrants invited to BreastScreen Norway. Methods: We included information about 2, 763,230 invitations and 2,087,222 screening examinations from 805,543 women aged 50–69 years who were invited to BreastScreen Norway between ...
    • Early screening outcomes before, during, and after a randomized controlled trial with digital breast tomosynthesis 

      Holen, åsne Sørlien; Bergan, Marie Burns; Lee, Christoph I.; Zackrisson, Sophia; Moshina, Nataliia; Aase, Hildegunn Siv; Haldorsen, Ingfrid S.; Hofvind, Solveig Sand-Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-01)
      Purpose: To describe and compare early screening outcomes before, during and after a randomized controlled trial with digital breast tomosynthesis (DBT) including synthetic 2D mammography versus standard digital mammography (DM) (To-Be 1) and a follow-up cohort study using DBT (To-Be 2). <p><p>Methods: Retrospective results of 125,020 screening examinations from four consecutive screening rounds ...
    • Effect of invitation letter in language of origin on screening attendance: randomised controlled trial in BreastScreen Norway 

      Hofvind, Solveig Sand-Hanssen; Iqbal, Nadia; Thy, Jonas Evensen; Mangerud, Gunhild; Bhargava, Sameer; Zackrisson, Sophia; Berstad, Paula (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-19)
      Objective<p> <p>To explore attendance at organised mammographic screening among immigrant groups that received an invitation letter and information leaflet (invitation) in their language of origin and Norwegian compared with Norwegian only.<p> <p>Design <p>Randomised controlled trial. <p>Setting <p>Population based screening programme for breast cancer in Norway (BreastScreen Norway), which invites ...
    • Experience of pain during mammographic screening by three different compression paddles 

      Moshina, Nataliia; Sagstad, Silje; Holen, åsne Sørlien; Backmann, Heinrich August; Westermann, L.C.; Hofvind, Solveig Sand-Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-13)
      Introduction - Experience of pain during screening mammography is shown to affect further attendance negatively. We aimed to explore the experience of pain during screening mammography using three different breast compression paddles.<p> <p>Methods - Using a self-report questionnaire, we collected information on pain experienced during mammography from 938 women screened in Bodø at Nordland ...
    • Fatal and non-fatal breast cancers in women targeted by BreastScreen Norway: a cohort study 

      Tsuruda, Kaitlyn; Hoff, Solveig Kristin Roth; Akslen, Lars Andreas; Hofvind, Solveig Sand-Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-04)
      Background - Many breast cancer survivors experience anxiety related to dying from their disease even if it is detected at an early stage. We aimed to increase knowledge about fatal and non-fatal breast cancer by describing how histopathological tumour profiles and detection modes were associated with 10-year breast cancer-specific survival.<p> <p>Methods - This cohort study included data from ...
    • Impact of the COVID-19 pandemic on breast cancer incidence and tumor stage in the Netherlands and Norway: A population-based study 

      Eijkelboom, Anouk H.; de Munck, Linda; Larsen, Marthe; Bijlsma, Maarten J.; Tjan-Heijnen, Vivianne C.G.; van Gils, Carla H.; Broeders, Mireille J.M.; Nygård, Jan Franz; Lobbes, Marc B.I.; Helsper, Charles W.; Pijnappel, Ruud M.; Strobbe, Luc J.A.; Wesseling, Jelle; Hofvind, Solveig Sand-Hanssen; Siesling, Sabine (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-27)
      Background - Comparing the impact of the COVID-19 pandemic on the incidence of newly diagnosed breast tumors and their tumor stage between the Netherlands and Norway will help us understand the effect of differences in governmental and social reactions towards the pandemic.<p< <p>Methods - Women newly diagnosed with breast cancer in 2017–2021 were selected from the Netherlands Cancer Registry and ...
    • Low-dose aspirin and risk of breast cancer: a Norwegian population-based cohort study of one million women 

      Løfling, Lukas; Støer, Nathalie Charlotte; Nafisi, Sara; Ursin, Giske; Hofvind, Solveig Sand-Hanssen; Botteri, Edoardo (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-06)
      Several studies evaluated the association between aspirin use and risk of breast cancer (BC), with inconsistent results. We identifed women aged≥50 years residing in Norway between 2004 and 2018, and linked data from nationwide registries; including the Cancer Registry of Norway, the Norwegian Prescription Database, and national health surveys. We used Cox regression models to estimate the ...
    • Mammografiprogrammet – tidligere, i dag og i fremtiden 

      Holen, åsne Sørlien; Mangerud, Gunhild; Hofvind, Solveig Sand-Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-12)
      Mammografiprogrammet (engelsk: BreastScreen Norway) er det offentlige screeningprogrammet for brystkreft i Norge. Det startet som et pilotprosjekt i 1995 og ble gradvis landsdekkende frem til 2005. Programmet inviterer alle kvinner i alderen 50-69 år til mammografiscreening hvert annet år. Kreftregisteret har det administrative ansvaret for Mammografiprogrammet, mens screening skjer ved 30 ...
    • Mammographic density and interval cancers in mammographic screening: Moving towards more personalized screening 

      Larsen, Marthe; Lynge, Elsebeth; Lee, Christoph I.; Lång, Kristina; Hofvind, Solveig Sand-Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-21)
      Purpose: The European Society on Breast Imaging has recommended supplemental magnetic resonance imaging (MRI) every two to four years for women with mammographically dense breasts. This may not be feasible in many screening programs. Also, the European Commission Initiative on Breast Cancer suggests not implementing screening with MRI. By analyzing interval cancers and time from screening to ...
    • Mammographic features and risk of breast cancer death among women with invasive screen-detected cancer in BreastScreen Norway 1996–2020 

      Moshina, Nataliia; Backmann, Heinrich August; Skaane, Per; Hofvind, Solveig Sand-Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-08)
      Objectives We explored associations between mammographic features and risk of breast cancer death among women with small (<15 mm) and large (≥15 mm) invasive screen-detected breast cancer.<p> <p>Methods We included data from 17,614 women diagnosed with invasive breast cancer as a result of participation in BreastScreen Norway, 1996–2020. Data on mammographic features (mass, spiculated mass, ...
    • Norwegian radiologists’ expectations of artificial intelligence in mammographic screening – A cross-sectional survey 

      Martiniussen, Marit Almenning; Larsen, Marthe; Larsen, Anne Sofie Frøyshov; Hovda, Tone; Koch, Henrik Wethe; Bjørnerud, Atle; Hofvind, Solveig Sand-Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-23)
      Purpose: To explore Norwegian breast radiologists’ expectations of adding artificial intelligence (AI) in the interpretation procedure of screening mammograms.<p> <p>Methods: All breast radiologists involved in interpretation of screening mammograms in BreastScreen Norway during 2021 and 2022 (n = 98) were invited to take part in this anonymous cross-sectional survey about use of AI in mammographic ...